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The blood-only liquid biopsy test for residual disease detection & recurrence surveillance

Guardant Reveal detects circulating tumor DNA (ctDNA) for minimal residual disease (MRD) assessment in Stage II and Stage III colorectal cancer (CRC) patients. In addition to detection of MRD, Guardant Reveal is available to monitor for recurrence of CRC in previously diagnosed patients.

Blood-only liquid biopsy test.

Guardant Reveal for patients with Stage II/III CRC

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Post-Surgery Decision Making

Identify patients at high risk for recurrence to help guide decisions about adjuvant therapy
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Monitor for early signs of recurrence

The importance of detecting ctDNA

The detection of ctDNA post-surgery for CRC patients can be a sign of the need for adjuvant chemotherapy. While 80% of Stage II CRC patients are cured with surgery alone, within 5 years approximately 10% of Stage II CRC patients and 30% of Stage III CRC patients recur.¹ Current clinicopathologic tools, like CEA, are limited in their ability to identify patients at high risk for recurrence.

Guardant’s proprietary technology detects the presence of ctDNA in the blood. Patients with ctDNA detected have a high likelihood of recurrence (100% PPV in clinical study²) and may benefit from additional therapy. This blood-only test addresses the challenge of tissue insufficiency in the tumor-dependent approach that requires an initial sequencing of tumor tissue to guide ctDNA detection.

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91% Sensitivity²

Repeat testing in the surveillance setting offers more opportunity to detect ctDNA as an early sign of recurrence. In a study published in Clinical Cancer Research, Guardant Reveal reached 91% sensitivity to detect ctDNA in patients who had a blood draw within 4 months of recurrence.

Circulating tumor DNA (ctDNA) genomic alteration.
Genomic Alterations
Circulating tumor DNA (ctDNA) methylation.


Navigate with confidence

In the surveillance setting, Guardant Reveal maximizes sensitivity for detecting ctDNA by simultaneously interrogating two complementary signals, genomic alterations and DNA methylation.

Tumors evolve and mutate over time. Unlike tests that rely on a static "snapshot" of a tumor, Guardant Reveal examines a wide range of genomic and epigenomic markers through a series of planned blood draws. This process allows for sensitive monitoring for recurrence in CRC patients.

Delivering fast, reliable test results

Guardant Reveal delivers results in 2 weeks and does not require tissue to initiate, eliminating the delays associated with assays that require tissue and the challenge of inadequate tissue samples. In addition, Guardant Reveal can be initiated as soon as 4 weeks after surgery.

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Guardant Portal App.

Access continuous support with Guardant Portal

Offering easy access to your patients’ results and support services, the Guardant Portal provides everything you need for informed treatment planning, including:

• End-to-end support to manage billing
• On-call clinical support for you and your staff


  1. Tsikitis, V.L., Larson, D.W., Huebner, M. et al. Predictors of recurrence free survival for patients with stage II and III colon cancer. BMC Cancer 14, 336 (2014).
  2. Parikh A, Van Seventer E, Siravegna G, Hartwig A, et al. Minimal Residual Disease Detection using a Plasma-Only Circulating Tumor DNA Assay in Colorectal Cancer Patients. Under Review. Data on file.
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